?Fig.3e).3e). ATP:ADP ratio, mitochondrial-specific H2O2 deposition, Drp-1-mediated mitochondrial fragmentation, and endoplasmic reticulumCmitochondrial dissociation. Primary disruption preceded measurable boosts in whole-cell oxidative tension, misfolded protein content material, transcriptional UPR activation, and its own untoward downstream results: CHOP appearance, PARP cleavage, and cell loss of life. Geranylgeranylacetone, a healing that boosts cell chaperone articles, avoided mitochondrial TLR3 […]